Targeted agents for nerve regeneration

Details Targeted agents for nerve regeneration Targeted agents for nerve regeneration

A - Human Necessities

61

K

A61K 38/45 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) C07K 14/11 (2006.01) C07K 14/31 (2006.01) C07K 14/315 (2006.01) C07K 14/32 (2006.01) C07K 14/33 (2006.01) C07K 19/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2492806

A conjugate, for delivery of a therapeutic agent to a neuronal cell, comprises the therapeutic agent, a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the binding domain is Hc of botulinum C1 toxin or is based thereon.

L'invention porte sur un conjugué servant à la distribution d'un agent thérapeutique à une cellule neuronale comprenant: l'agent thérapeutique, un domaine de fixation se fixant à la cellule neuronale, et un domaine de translocation de l'agent thérapeutique dans la cellule neuronale, le domaine de fixation étant la toxine H¿c? du botulinum C¿1? ou se basant sur elle.

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