C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01)
Patent
CA 2509508
The present invention relates to TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for. various hepatic diseases and an antitumor agent.
Goto Masaaki
Higashio Kanji
Kinosaki Masahiko
Kobayashi Fumie
Murakami Akihiko
Atlas Pharmaceuticals Inc.
Daiichi Pharmaceutical Co. Ltd.
Dennison Associates
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