Technetium (111/11) imaging agents

Details Technetium (111/11) imaging agents Technetium (111/11) imaging agents

C - Chemistry, Metallurgy

07

F

260/210, 260/383

C07F 13/00 (2006.01) A61K 49/02 (1990.01)

Patent

CA 2009585

Technetium (III/II) Imaging Agent Abstract A ligated technetium (III/II) complex is useful as a brain perfusion imaging agent. The complex has a technetium (III/II) center surrounded by six ligating moieties. The complex preferably has a reduction potential Tc(III) to Tc(II) which is less than about +0.6 volts vs Ag/AgCl (3M NaCl) and at least low enough to be oxidized in vivo after crossing the blood brain diffusion barrier. The technetium complex has six ligating moieties, four of which use phosphorous, arsenic, or nitrogen as ligating atoms. The remaining two ligands use sulfur or selenium to complex to the Tc center. These ligands are modified to establish an effective oxidation potential of the Tc(II) thus providing the necessary redox potential for in vivo oxidation.

Affiliated with

Also associated with

Rating

Technetium (111/11) imaging agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Technetium (111/11) imaging agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Technetium (111/11) imaging agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1693871