Template associated npy y2-receptor agonists

Details Template associated npy y2-receptor agonists Template associated npy y2-receptor agonists

C - Chemistry, Metallurgy

07

K

C07K 7/02 (2006.01) A61K 38/22 (2006.01) C07K 1/107 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326146

The present invention is directed to agonists of neuropeptide Y (NPY) or PYY that are formed by combining these peptides or a portion of these peptides with a template that promotes biologically active folds. Typically, templates consist of cyclized peptides containing one or more naphthyl ring structures. The agonists may be used in the treatment of diseases and conditions known to be responsive to NPY or PYY and, particularly in the treatment of asthma, rhinitis, and bronchitis.

La présente invention concerne des agonistes des neuropeptides Y (NPY) ou PYY, que l'on peut former en combinant ces peptides, ou une partie de ceux-ci, avec une matrice destinée à favoriser les plis biologiquement actifs. Une telle matrice est généralement constituée de peptides cyclisés contenant une ou plusieurs structures à cycle naphtyle. Les agonistes de cette invention peuvent être utilisés pour traiter les maladies et les troubles liés aux peptides NPY ou PYY, en particulier l'asthme, la rhinite, et la bronchite.

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