C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 51/09 (2006.01) A61K 31/192 (2006.01) A61P 25/28 (2006.01) C07C 57/38 (2006.01) C07C 57/58 (2006.01) C07C 59/64 (2006.01) C07D 257/04 (2006.01)
Patent
CA 2649845
The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of .gamma.-secretase activity.
L'invention concerne les composés de formule générale (I), dans laquelle X, Y, R1, R2, R3, R4, R9, R10 sont tels que définis ci-dessous, ainsi que les solvates, hydrates, esters et sels pharmaceutiquement acceptables de ceux-ci. De plus, l'invention concerne l'utilisation desdits composés dans le traitement de la maladie d'Alzheimer ainsi que dans la modulation de l'activité de la .gamma.-sécrétase.
Boussard Cyrille
Burckhardt Svenja
Cansfield Andrew
Harrison Richard John
Hernadez-Perni Remedios
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cellzome Limited
Ortho-Mcneil Pharmaceutical Inc.
Ortho-Mcneil-Janssen Pharmaceuticals Inc.
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