Tetra-substituted benzene derivatives

Details Tetra-substituted benzene derivatives Tetra-substituted benzene derivatives

C - Chemistry, Metallurgy

07

C

260/227, 260/489

C07C 69/78 (2006.01) C07C 45/54 (2006.01) C07C 45/62 (2006.01) C07C 45/71 (2006.01) C07C 45/74 (2006.01) C07C 49/84 (2006.01) C07C 65/24 (2006.01) C07D 213/40 (2006.01) C07D 307/12 (2006.01) C07D 317/54 (2006.01) C07D 317/58 (2006.01) C07D 333/20 (2006.01) C07F 9/12 (2006.01) C07H 15/203 (2006.01)

Patent

CA 1206964

ABSTRACT Novel compounds of the general formula Image I wherein X represents an oxygen or sulphur atom or hydroxyimino; Y represents methylene or imino; R1 represents a hydroxy, phosphonooxy, glycosyloxy, acylated glycosyloxy, acyloxy or lower alkoxycar- bonyloxy; R2 represents lower alkoxy, lower alkenyloxy or lower alkylthio; R3 represents lower alkoxy; R4 represents lower alkyl, p-lower-alkoxy-benzoyl or a substituted or unsubstituted phenyl, benzyl, pyridyl- methyl, furfuryl, tetrahydrofurfuryl, thenyl tetra- hydrothenyl, pyrrolylmethyl, pyrrolinylmethyl or pyrrolidinylmethyl group, with the proviso that when R4 represents alkyl, a phenyl including lower alkyloxy phenyl, benzyl or p-hydroxybenzyl, Y does not represent a methylene radical; and with the further proviso that when R4 represents p-methoxybenzyl and Y represents methylene, R2 and R3 are different, and pharmaceutically acceptable salts thereof, possess antiviral activity. The compounds of formula I can be prepared by various methods.

388364

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