Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands

Details Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands Tetrahydro-5h-pyrido[2,3-d]azepines as 5-ht2c ligands

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/55 (2006.01) A61P 3/04 (2006.01)

Patent

CA 2692440

Compounds according to Formula (I); wherein the radical R preferably represents a hetereocycle of 6 or 7 members and R4, R9-12 all preferably represent hydrogen atoms. These compounds and their pharmaceutical acceptable salts are used in pharmaceutical compositions and are useful for treating serotonin 5HT2c receptor mediated diseases. Processes to make such derivatives are as well disclosed therein.

L'invention concerne des composés représentés par la Formule (I); dans laquelle le radical R7 représente de préférence un hétérocycle de 6 ou 7 chaînons et R4, R9-12 représentent tous de préférence des atomes d'hydrogène. Ces composés et leurs sels pharmaceutiquement acceptables sont utilisés dans des compositions pharmaceutiques et sont utiles pour le traitement de maladies médiées par les récepteurs 5HT2C de la sérotonine. L'invention concerne également des procédés de fabrication de ces dérivés.

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