Tetrahydroquinoline compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 215/233 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61P 5/26 (2006.01) A61P 5/28 (2006.01) A61P 7/06 (2006.01) A61P 13/08 (2006.01) A61P 15/00 (2006.01) A61P 15/08 (2006.01) A61P 15/10 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 19/10 (2006.01) A61P 21/00 (2006.01) A61P 35/00 (2006.01) C07D 215/36 (2006.01) C07D 215/42 (2006.01) C07D 215/44 (2006.01) C07D 215/48 (2006.01) C07D 401/04 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2422137

Tetrahydroquinoline compounds represented by the following general formula (I), which have a specific and potent AR-binding affinity, exhibit an AG agonistic or antagonistic effect and exert therapeutic effects on diseases mediated by AR (in particular, exerting potent effects on skeleton muscular tissues and bone tissues without showing any excessive effect on the prostate as an AR agonist), or pharmacologically acceptable salts thereof and medicinal compositions containing the same as the active ingredient: (I)

L'invention concerne des composés de tétrahydroquinoline représentées par la formule générale (I), présentant une affinité de liaison puissante et spécifique avec le récepteur androgène (AR). Ces composés possèdent un effet agoniste ou antagoniste vis-à-vis de AR, et exercent des effets thérapeutiques sur des maladies induites par AR (en particulier des effets puissants sur les tissus musculaires squelettiques et les tissus osseux, sans présenter d'effets excessifs sur la prostate en tant qu'agoniste de AR). L'invention concerne également des sels pharmaceutiquement acceptables desdits composés et des compositions médicales les contenant sous forme de principe actif.

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