Tetralin and indane derivatives and uses thereof

Details Tetralin and indane derivatives and uses thereof Tetralin and indane derivatives and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 317/32 (2006.01) C07C 317/44 (2006.01) C07D 207/16 (2006.01) C07D 207/32 (2006.01) C07D 207/34 (2006.01) C07D 207/36 (2006.01) C07D 209/30 (2006.01) C07D 231/18 (2006.01) C07D 233/54 (2006.01) C07D 233/84 (2006.01) C07D 233/88 (2006.01) C07D 233/90 (2006.01) C07D 235/06 (2006.01) C07D 239/14 (2006.01) C07D 239/42 (2006.01)

Patent

CA 2591937

Compounds of the formula (I), or pharmaceutically acceptable salts thereof, wherein R2 is (CR3R4)n-NR5R6 and m, p, q, Ar, R1, R3, R4, R5 and R6 are as defined in the claims, which are selective antagonists of 5-HT6 and/or 5-HT2A. Also provided are compositions comprising these compounds and their use in the preparation of medicaments for treating central nervous system disease states selected from psychoses, schizophrenia, manic depressions, neurological disorders, memory disorders, attention deficit disorder, Parkinson~s disease, amyotrophic lateral scierosis, Alzheimer~s disease, food uptake disorders and Huntington~s disease.

Cette invention concerne des composés représentés par la formule (I), ou bien des sels pharmaceutiquement acceptables de ces composés, dans laquelle R2 est (CR3R4)n-NR5R6 et m, p, q, Ar, R1, R3, R4, R5 et R6 sont comme définis dans les revendications. Ces composés sont des antagonistes sélectifs de 5-HT6 et/ou de 5-HT2A. L'invention concerne également des compositions contenant ces composés et leur utilisation dans la fabrication de médicaments intervenant dans le traitement d'états pathologiques du système nerveux central telles que psychoses, schizophrénie, psychose maniaco-dépressive, troubles neurologiques, troubles de la mémoire, déficit de l'attention, maladie de Parkinson, sclérose latérale amyotrophique, maladie d'Alzheimer, troubles d'absorption des aliments et maladie de Huntington.

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