Tfpi inhibitors and methods of use

Details Tfpi inhibitors and methods of use Tfpi inhibitors and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 38/17 (2006.01) A61K 38/36 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 7/08 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2747721

The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject.

L'invention concerne des peptides qui se lient à l'inhibiteur de la voie du facteur tissulaire (TFPI), y compris les peptides inhibiteurs de TFI, et leurs compositions. Les peptides peuvent être utilisés pour inhiber un TFPI, pour améliorer la formation de thrombine chez un sujet souffrant d'une carence de facteurs de coagulation, pour augmenter la formation de caillot sanguin chez un sujet et/ou pour traiter un trouble de la coagulation sanguine chez un sujet.

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