The preparation of active peptides

Details The preparation of active peptides The preparation of active peptides

C - Chemistry, Metallurgy

07

K

C07K 11/00 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2223911

The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R1 and R2 have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.

L'invention concerne un procédé de préparation de pentapeptides de la formule (I) dans laquelle A et R<1>-R<3> ont la notation mentionnée. Ce procédé se caractérise en ce que le pentapeptide est structuré par étape à partir d'un prolinamide de la formule (II) dans laquelle R<1> et R<2> ont la notation précitée, et le groupe -NR<1>R<2> peut être séparé par voie hydrolytique du peptide ainsi obtenu.

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