The semi-synthesis of a protected bacatin iii compound

Details The semi-synthesis of a protected bacatin iii compound The semi-synthesis of a protected bacatin iii compound

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2188190

The present invention relates to a semi-synthetic process to convert a naturally occurring taxane into a suitable starting material for the synthesis of paclitaxel (Taxol R) and related compounds. Specifically, the present invention relates to a process for the conversion of 9-dihydro-13-acetylbaccatin III into a 7-protected baccatin III which can then be used as starting material for the synthesis of taxane derivatives such as paclitaxel, docetaxel, cephalomannine and other taxanes structurally related to baccatin III. The method as described uses a preparative scale technique which is amenable to commercial scale-up.

L'invention porte sur un procédé semi-synthétique pour convertir un taxane naturel en une matière de départ pour la synthèse de paclitaxel (Taxol R) et de composés apparentés. Plus précisément, l'invention porte sur un procédé pour la conversion de la 9-dihydro-13-acétylbaccatine III en une baccatine III protégée en 7, qui peut servir comme matière de départ pour la synthèse de dérivés du taxane, p. ex. paclitaxel, docétaxel, céphalomannine et d'autres taxanes apparentés structurellement à la baccatine III. La méthode telle que décrite utilise une technique d'échelle préparatoire pouvant être adaptée à la mise à l'échelle commerciale.

Affiliated with

Also associated with

Rating

The semi-synthesis of a protected bacatin iii compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with The semi-synthesis of a protected bacatin iii compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The semi-synthesis of a protected bacatin iii compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1785992