A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/08 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2524626
The present invention relates to the use of a polypeptide domain to modulate the tumorigenic and metastatic potential of cancer cells. More specifically, the present invention relates to a domain of a Secretory Leukocyte Protease Inhibitor (SLPI) to modulate tumor invasiveness and/or metastasis. It further relates to compounds, such as antibodies, that interact with said domain and repress the tumor invasiveness and/or the metastasis.
La présente invention concerne l'utilisation d'un domaine polypeptidique pour moduler le potentiel tumorigène et métastatique de cellules cancéreuses. Cette invention concerne plus spécifiquement un domaine d'un inhibiteur de la protéase leucocytaire sécrétoire (SLPI) utilisé pour moduler le pouvoir envahissant d'une tumeur et/ou la métastase. Cette invention concerne en outre des composés, tels que des anticorps, qui interagissent avec ce domaine et répriment le pouvoir envahissant d'une tumeur et/ou la métastase.
de Baetselier Patrick
Devoogdt Nick
Hassanzadeh Ghassabeh Gholamreza
Revets Hilde
Fetherstonhaugh & Co.
Vib Vzw
Vrije Universiteit Brussel
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