G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2499685
The present invention relates to the use of molecular markers and related signaling mechanisms for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity. The invention also relates to the use of such markers as diagnostic and/or prognostic tools for the treatment of tumor patients with such inhibitors.
La présente invention se rapporte à l'utilisation de marqueurs moléculaires et à des mécanismes de signalisation associés pour le profilage préclinique et clinique d'inhibiteurs d'enzymes possédant une activité d'histone-désacétylase. L'invention se rapporte également à l'utilisation de ces marqueurs en tant qu'outils diagnostiques et/ou pronostiques pour le traitement de patients présentant des tumeurs au moyen de ces inhibiteurs.
Giuseppe Pelicci Pier
Golebiewski Martin
Gottlicher Martin
Heinzel Thorsten
Hentsch Bernd
Forschungszentrum Karlsruhe Gmbh
G2m Cancer Drugs Ag
Goudreau Gage Dubuc
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