Therapeutic agents

Details Therapeutic agents Therapeutic agents

C - Chemistry, Metallurgy

07

C

C07C 235/40 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 233/63 (2006.01) C07C 237/24 (2006.01) C07C 271/12 (2006.01) C07C 271/22 (2006.01) C07C 279/14 (2006.01) C07C 311/05 (2006.01) C07C 311/06 (2006.01) C07D 207/14 (2006.01) C07D 295/15 (2006.01) C07D 317/40 (2006.01)

Patent

CA 2067223

2067223 9108195 PCTABS00005 Compounds of formula (I) are diuretic agents for treating various cardiovascular diseases including hypertension, heart failure and renal insufficiency. Formula (I), wherein A completes a 4-to-7-membered saturated or unsaturated carbocyclic ring optionally fused to a further saturated or unsatured 5-or-6-membered carbocyclic ring, R and R4 are H, C1-C6 alkyl, benzyl or a biolabile ester-forming group, R1 is H or C1-C4 alkyl, R2, R3, R18 and R19 are H, C1-C6 alkyl, C1-C4 alkoxy, aryl (C1-C6) alkyl, aryl (C2-C6) alkenyl, aryl (C1-C6) alkoxy (C1-C4) alkyl or hydroxy (C1-C4) alkyl, or R2 and R18 form 2-indanylidene, and R5 includes a range of alkyl, alkenyl, alkynyl, cycloalkyl, cylcloalkenyl and substituted alkyl including S-lysylaminomethyl, N2-acetyl-S-lysylaminomethyl and N2-methanesulphonyl-S-lysylaminomethyl.

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