Therapeutic agents for sensory disorders

Details Therapeutic agents for sensory disorders Therapeutic agents for sensory disorders

A - Human Necessities

61

K

A61K 31/122 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2595208

A therapeutic agent for sensory abnormality represented by the following general formula (1): (1) (wherein R1, R2 and R3 each represents a hydrogen atom or a methyl group, and X represents a linear or branched alkylene or alkenylene group having 10 to 28 carbon atoms) is provided. A cyclohexenone long-chain alcohol of the invention improves hyperalgesia or dullness, therefore it is useful as a therapeutic agent for sensory abnormality. Examples of the sensory abnormality that can be prevented or treated according to the invention include chronic intractable pain, psychogenic pain, decreased pain threshold caused by nerve damage, hypoesthesia or hyperesthesia caused by nerve damage or diabetes and the like.

La présente invention concerne un agent thérapeutique pour le traitement d'une anomalie sensorielle représentée par la formule générale suivante (1): (1) (R1, R2 et R3 représentant chacun un atome d~hydrogène ou un groupe méthyle, et X représentant un groupe alkylène ou alkénylène linéaire ou ramifié ayant 10 à 28 atomes de carbone). Un alcool à longue chaîne de type cyclohexène décrit dans l~invention améliore l~hyperalgésie ou l~apathie et est donc utile en tant qu'agent thérapeutique pour le traitement d~une anomalie sensorielle. Parmi les exemples d~anomalie sensorielle pouvant être prévenue ou traitée selon l~invention figurent la douleur chronique réfractaire, la douleur psychogène, la baisse du seuil de la douleur résultant de lésions nerveuses, l~hypoesthésie ou l~hyperesthésie résultant de lésions nerveuses, d~un diabète ou d~un trouble analogue.

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