Therapeutic and delivery methods of prostaglandin ep4 agonists

Details Therapeutic and delivery methods of prostaglandin ep4 agonists Therapeutic and delivery methods of prostaglandin ep4 agonists

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2585367

A compound comprising a prodrug of a prostaglandin EP4 agonist, wherein said prodrug is an ester, ether, or amide of a carbohydrate; or said prodrug is an ester, ether, or amide of an amino acid is disclosed herein. Maintenance of the colonic mucosal barrier by method comprising administering a therapeutically effective amount of a prostaglandin EP4 agonist to a colon of a mammal is also disclosed herein. Dosage forms, medicaments, and compositions, related thereto are also disclosed.

Composé contenant un promédicament d'un agoniste de prostaglandine EP4, ledit promédicament étant un ester, éther ou amide d'un hydrate de carbone ou étant un ester, éther or amide d'un acide aminé. L'objet de la présente invention est le rétablissement de la barrière muqueuse du colon par une méthode consistant à administrer une quantité thérapeutiquement efficace d'un agoniste de prostaglandine EP4 au colon d'un mammifère. Des formes galéniques, des médicaments et des compositions correspondants sont également décrits.

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