Therapeutic polypeptides and methods for using same

Details Therapeutic polypeptides and methods for using same Therapeutic polypeptides and methods for using same

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/24 (2006.01) A61K 48/00 (2006.01) C07K 14/59 (2006.01) C07K 16/26 (2006.01) C07K 16/42 (2006.01) C12N 1/21 (2006.01) C12N 5/12 (2006.01) C12N 15/62 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2381005

The invention relates to therapeutic polypeptides originally isolated from human early pregnancy urine, now synthet- ically produced, as well as functional equivalents of these polypeptides. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypep- tides include anti-HIV, anti-cancer, anti-wasting, pro-hematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.

L'invention concerne des polypeptides thérapeutiques originellement isolés dans l'urine de femme enceinte précoce, aujourd'hui produits synthétiquement, ainsi que des équivalents fonctionnels de ces polypeptides. Les polypeptides thérapeutiques et leurs équivalents fonctionnels sont utiles dans le traitement et/ou la prévention de diverses conditions médicales. Les effets anti-VIH, anticancéreux, anti-dégénératifs, pro-hématopoïétiques ( par exemple anémie, altération de la moelle osseuse induite par des rayonnements, perte de sang induite par des trauma) et antiangiogéniques sont des exemples de l'action thérapeutique des polypeptides thérapeutiques. L'invention traite également de compositions pharmaceutiques comprenant des polypeptides thérapeutiques, ainsi que de procédés conçus pour utiliser ces polypeptides, leurs équivalents fonctionnels et/ou des compositions pharmaceutiques dans le traitement et/ou la prévention de telles conditions médicales.

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