Therapeutic treatment methods

Details Therapeutic treatment methods Therapeutic treatment methods

A - Human Necessities

61

K

A61K 31/56 (2006.01)

Patent

CA 2496867

The invention relates to the use of compounds to ameliorate or treat an condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3.beta.-hydroxy- 17.beta.-aminoandrost-5-ene, 3.beta.-hydroxy-16.alpha.-fluoro-17.beta.- aminoandrost-5-ene, 3.alpha.-hydroxy-16.alpha.-fluoro-17.beta.-aminoandrost-5- ene, 3.beta.-hydroxy-16.beta.-fluoro-17.beta.-aminoandrost-5-ene, 1.alpha.,3.beta.-dihydroxy-4.alpha.-fluoroandrost-5-ene-17-one, 1.alpha.,3.beta., 17.beta.-trihydroxy-4.alpha.-fluorandrost-5-ene, 1.beta.,3.beta.-dihydroxy-6.alpha.-bromoandrost-5-ene, 1.alpha.-fluoro- 3.beta.,12.alpha.-dihydroxyandrost-5-ene-17-one, 1.alpha.-fluoro- 3.beta.,4.alpha.-dihydroxyandrost-5-ene and 4.alpha.-fluoro-3.beta.,6.alpha., 17.beta.-trihydroxyandrostante.

L'invention concerne l'utilisation de composés visant à améliorer ou à traiter un état tel que mucoviscidose, neutropénie ou d'autres états présentés. Les composés exemplaires que l'on peut utiliser comprennent 3.beta.-hydroxy-17.beta.-amino-androst-5-ène, 3.beta.-hydroxy-16.alpha.-fluoro-17.beta.-amino-androst-5-ène, 3.alpha.-hydroxy-16.alpha.-fluoro-17.beta.-amino-androst-5-ène, 3.beta.-hydroxy-16.beta.-fluoro-17.beta.-amino-androst-5-ène, 1.alpha.,3.beta.-dihydroxy-4.alpha.-fluoro-androst-5-ène-17-one, 1.alpha.,3.beta., 17.beta.-trihydroxy-4.alpha.-fluoro-androst-5-ène, 1.beta.,3.beta.-dihydroxy-6.alpha.-bromo-androst-5-ène, 1.alpha.-fluoro-3.beta.,12.alpha.-dihydroxy-androst-5-ène-17-one, 1.alpha.-fluoro-3.beta.,4.alpha.-dihydroxy-androst-5-ène and 4.alpha.-fluoro-3.beta.,6.alpha., 17.beta.-trihydroxyandrostane.

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