A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/02 (2006.01) A61K 38/16 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2621939
The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
Le gène ospF de Shigella flexneri code pour une phosphatase qui est membre d'une nouvelle classe de phosphatases. La phosphatase OspF inhibe l'activité de plusieurs protéines par modification directe de celles-ci ou par régulation à la baisse de la transcription. Parmi lesdites protéines, on peut citer les suivantes : MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, et protéines associées à la famille BCL2. L'invention concerne des méthodes de traitement de maladies au moyen de la phosphatase OspF, des méthodes d'identification d'agents qui modulent l'activité de la phosphatase OspF, des méthodes d'identification d'agents qui reproduisent l'activité de la phosphatase OspF, et des compositions immunogènes comprenant la phosphatase OspF. L'invention concerne également une souche de Shigella flexneri contenant un gène ospF inactivé.
Arbibe Laurence
Dong Wook Kim
Parsot Claude
Phalipon Armelle
Sansonetti Philippe
Inserm (institut National de La Sante Et de La Recherche Medical
Institut Pasteur
Robic
LandOfFree
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