Therapeutic use of rank antagonists

Details Therapeutic use of rank antagonists Therapeutic use of rank antagonists

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2447518

Provided herein are methods of treating various medical conditions that require the formation of new bone by administering an effective amount of a RANK antagonist. Antagonists suitable for use in the subject methods include soluble RANK polypeptides that bind RANKL, antisense oligonucleotides that inhibit RANK activity, antibodies specific for RANK or RANKL and osteoprotegerin.

L'invention concerne des méthodes de traitement de divers états pathologiques nécessitant une nouvelle formation osseuse, ces méthodes consistant à administrer une quantité suffisante d'un antagoniste de RANK. Les antagonistes aptes à être utilisés dans les méthodes faisant l'objet de cette invention comprennent des polypeptides RANK solubles qui lient RANKL, des oligonucléotides antisens qui inhibent l'activité de RANK, des anticorps spécifiques pour RANK ou RANKL et de l'ostéoprotegerine.

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