A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61K 38/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2651805
Described is a method of modulating the activation of a Rho, Arf, Rab, Ran or Rap family protein, said method comprising administering to said sample a USP-17 modulator, for example an inhibitor of expression or activity of DUB-3. The invention enables the use of USP-17 modulators in the treatment of metastatic cancer and other conditions.
L'invention concerne un procédé de modulation de l'activation d'une famille de protéines Rho, Arf, Rab, Ran ou Rap, ledit procédé impliquant d'administrer audit échantillon un modulateur USP-17, par exemple un inhibiteur de l'expression ou de l'activité de DUB-3. L'invention permet l'utilisation de modulateurs USP-17 dans le cadre du traitement des cancers à métastases et d'autres maladies.
Burrows James
Johnston James
Kelvin Alyson
Teitelbaum & Maclean
The Queen's University Of Belfast
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