Thiadiazole substituted coumarin derivatives and their use...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 19/02 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2600727

The instant invention provides compounds of Formula (Ia) which are leukotriene biosynthesis inhibitors, wherein X is O or S, Y is O, S, -NR6-CHR7- or -NR8- C(O)- and A is selected from 5-membered aromatic heterocyclic ring, 6-membered aromatic heterocyclic ring, naphthelenic or heterobicyclic aromatic ring system, phenyl and benzyl. A is optionally mono- or disubstituted. Compounds of Formula (Ia) are useful as anti-atherosclerotic, anti-asthmatic, anti- allergic, anti-inflammatory and cytoprotective agents.

La présente invention concerne des composés répondant à la formule (Ia) qui sont des inhibiteurs de biosynthèse de leucotriène, dans laquelle X représente O ou S, Y représente O, S, -NR6-CHR7- ou -NR8-C(O)- et A est choisi parmi un noyau aromatique hétérocyclique à 5 chaînons, un noyau aromatique hétérocyclique à 6 chaînons, un système de noyau aromatique naphtalénique ou hétérobicyclique, un groupe phényle et un groupe benzyle. A est éventuellement mono- ou disubstitué. Les composés répondant à la formule (Ia) sont utiles en tant qu~agents anti-athérosclérotique, anti-asthmatique, anti-allergique, anti-inflammatoire et cytoprotecteur.

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