Thiazole-4-carboxamide derivatives as mglur5 antagonists

Details Thiazole-4-carboxamide derivatives as mglur5 antagonists Thiazole-4-carboxamide derivatives as mglur5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/415 (2006.01) A61K 31/426 (2006.01) A61P 25/00 (2006.01) C07D 277/42 (2006.01) C07D 417/12 (2006.01) C07D 419/12 (2006.01)

Patent

CA 2593439

The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.

La présente invention concerne de nouveaux dérivés de thiazole 4-carboxyamide représentés par la formule générale (I), ainsi que des procédés de préparation de ces derniers, lesdits composés étant utiles en tant qu'antagonistes du récepteur de glutamate métabotropique. Dans la formule (I), R1 à R4 sont tels que définis dans la spécification.

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