Thiazolidine derivatives and methods for the preparation...

Details Thiazolidine derivatives and methods for the preparation... Thiazolidine derivatives and methods for the preparation...

C - Chemistry, Metallurgy

07

D

C07D 277/22 (2006.01) A61K 31/427 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 19/10 (2006.01) C07D 277/04 (2006.01) C07D 277/24 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2712109

The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a .beta.-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.

La présente invention concerne de nouvelles 2-carbonyl-3-acyl-1,3-thiazolidines comprenant un groupe ß-amino sur la chaîne acyle, sous forme libre ou sous la forme d'un promédicament ou d'un sel pharmaceutiquement acceptable correspondant, y compris leurs énantiomères, diastéréomères et racémates, ces composés étant utilisés comme inhibiteurs efficaces de la DPP-IV. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés. Elle se rapporte en outre à des procédés de préparation de ces composés ainsi qu'à des méthodes de traitement de maladies médiées par la DPP-IV.

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