C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/437 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2651769
There are presented compounds of the formula (I) wherein R1, R2, R3 and R4 are as defined in the description and claims, or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
La présente invention concerne des composés de formule (I) dans lesquels R1, R2, R3 et R4 sont tels que définis dans la description et les revendications, ou un sel pharmaceutiquement acceptable dérivé, qui sont des antagonistes actifs du récepteur d'adénosine A2B utiles pour traiter le diabète, la rétinopathie diabétique, l'asthme et la diarrhée.
Brinkman John A.
Cheung Adrian Wai-Hing
Firooznia Fariborz
Guertin Kevin Richard
Marcopulos Nicholas
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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