(thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 409/14 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2205584

This invention provides compounds having formula (I), wherein R is hydrogen, alkyl, alkenyl, alkynyl, -COR2, phenyl, or phenylalkyl of 7-10 carbon atoms; the dotted line represents an optional double bond; R1 is hydrogen, -OH, OR3, or is absent if the optional double bond is present; R2 and R3 are each, independently, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; R4 is hydrogen, -OR5, alkyl, alkenyl, alkynyl, -COR5, -CO2R5, -CONR5R6, perhaloalkyl, halogen, phenyl, or phenylalkyl; R5 and R6 are each, independently, hydrogen, alkyl, alkenyl, alkynyl, phenyl, or phenylalkyl; and n = 0 - 2 or a pharmaceutically acceptable salt thereof that are useful as antipsychotic, antidepressant and anxiolytic agents useful in the treatment and relief of the symptoms of these disease states.

La présente invention concerne des composés représentés par la formule (I), dans laquelle R désigne l'hydrogène, un alkyle, un alkényle, un alkynyle, -COR?2¿, un phényle, un phénylalkyle de 7 à 10 atomes de carbone; la ligne pointillée représente une double liaison facultative; R?1¿ est l'hydrogène, -OH, OR?3¿ ou est absent lorsque la double liaison facultative est présente; R?2¿ et R?3¿ désignent chacun, indépendamment, un alkyle, un alkényle, un alkynyle, un phényle ou un phénylalkyle; R?4¿ désigne l'hydrogène, -OR?5¿, un alkyle, un alkényle, un alkynyle, -COR?5¿, -CO¿2?R?6¿, un perhaloalkyle, un halogène, un phényle ou un phénylalkyle; R?5¿ et R?6¿ désignent chacun, indépendamment, l'hydrogène, un alkyle, un alkényle, un alkynyle, un phényle ou un phénylalkyle; et n = 0-2. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés qui sont utiles en tant qu'agents neuroleptiques, antidépressifs et anxiolytiques pour le traitement et le soulagement des symptômes liés à ces états pathologiques.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

(thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1934557

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.