Thioxanthenone antitumor agents

Details Thioxanthenone antitumor agents Thioxanthenone antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 335/16 (2006.01) A61K 31/38 (2006.01) A61K 31/67 (2006.01) C07F 9/6553 (2006.01)

Patent

CA 2070120

1-[[(Dialkylamino)alkyl]amino]-4-substituted- thioxanthen-9-ones of the formula: (see above formula) (wherein n is 2 or 3; R1 and R2 are each alkyl; Q is -CH2NHR3, -CH2NR4SO2R7, -CH2NHCHO, -CH=N-Ar, -CO-NR5R6, -CH2NR4COR7, -CH2N(C2H5) CHO or -CH2NR4PO(O-alkyl)2; R3, R4 and R6 are each H or alkyl; R5 is H, alkyl or Ar; R7 is alkyl or Ar; R8 is H, alkyl, alkoxy or halogen; and Ar is phenyl optionally substituted by methyl, methoxy, halogen or nitro) are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.

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