A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61L 27/12 (2006.01)
Patent
CA 2463481
The invention includes dispensing a suspension containing solid particles for use in manufacturing a dosage form or other biomedical article by 3DP. The suspension contains solid particles suspended in a liquid. The solid particles may be one or more Active Pharmaceutical Ingredients. The solid particles may be particles of material that are insoluble in the liquid, or they may be particles of a substance that have already dissolved in the liquid up to the saturation level and are present in a concentration beyond what can be dissolved. In addition to solid particles, the liquid may also contain other substances dissolved in it, either substances containing Active Pharmaceutical Ingredients (API) or substances without API. One aspect of the invention includes prevention of agglomeration by adding one or more of several categories of additives to the suspending liquid. Another aspect of the invention includes manipulating the surface charge of the particles in an API suspension to prevent particles from agglomerating. A further aspect of the invention includes an amorphous API that has a greater bioavailability than the corresponding crystalline material. Yet another aspect of the present invention includes a system for providing continuous circulation of the suspension such that the solid particles remain dispersed in the suspension.
L'invention concerne la distribution d'une suspension contenant des particules solides ~ utiliser dans la production d'une forme gal~nique ou d'un autre produit biom~dical par impression tridimensionnelle. Ladite suspension contient des particules solides en suspension dans un liquide. Lesdites particules solides peuvent Útre un ou plusieurs principes actifs pharmaceutiques. Lesdites particules solides peuvent Útre des particules d'une matire insoluble dans le liquide, ou des particules d'une substance d~j~ dissoute dans le liquide jusqu'au niveau de saturation, et sont pr~sentes en une concentration d~passant la quantit~ pouvant Útre dissoute. Outre les particules solides, le liquide peut ~galement contenir d'autres substances dissoutes, soit des substances contenant des principes actifs pharmaceutiques (API), soit des substances n'en contenant pas. Un aspect de l'invention concerne la pr~vention d'agglom~ration par ajout d'une ou de plusieurs cat~gories d'additifs audit liquide en suspension. Un autre aspect de l'invention concerne la manipulation de la charge de surface des particules dans une suspension de principes actifs pharmaceutiques afin d'empÚcher l'agglom~ration de particules. Un autre aspect de l'invention concerne un principe actif pharmaceutique amorphe qui pr~sente un biodisponibilit~ sup~rieure ~ celle de la matire cristalline correspondante. Un autre aspect de l'invention concerne un systme permettant d'obtenir une circulation continue de la suspension de sorte que les particules solides restent dispers~es dans la solution.
Bornancini Esteban R. N.
Cima Michael J.
Fairweather James A.
Gaylo Christopher M.
Pryce Lewis Wendy E.
Massachusetts Institute Of Technology
Oyen Wiggs Green & Mutala Llp
Therics Inc.
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