Thrombin inhibitors

Details Thrombin inhibitors Thrombin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/4995 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 471/04 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2348734

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the structure (I) or a pharmaceutically acceptable salt thereof, wherein b is NY1 or O; c is CY2 or N; d is CY3 or N; e is CY4 or N; f is CY5 or N; g is CY6 or N; Y4, Y5, and Y6 are independently hydrogen, C1-4 alkyl, or halogen; Y1 and Y2 are independently hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, NH2, OH or C1-4 alkoxy, and Y3 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl, halogen, -CN, NH2, OH or C1-4 alkoxy; A is (II), (III), (IV), (V) or (VI); and W, W1, R1, R3, R4, R5, X and Z are defined in the specification.

L'invention concerne des composés pouvant inhiber la thrombine et les occlusions thrombotiques associées, et présentant la structure de la formule (I), où b désigne NY?1¿ ou O ; c désigne CY?2¿ ou N ; d désigne CY?3¿ ou N ; e désigne CY?4¿ ou N ; f désigne CY?5¿ ou N ; g désigne CY?6¿ ou N ; Y?4¿, Y?5¿ et Y?6¿ désignent indépendamment l'hydrogène, un alkyle C¿1-4?, ou un halogène ; Y?1¿ et Y?2¿ désignent indépendamment l'hydrogène, un alkyle C¿1-4?, un cycloalkyle C¿3-7?, un halogène, NH¿2?, OH ou alcoxy C¿1-4?, et Y?3¿ désigne l'hydrogène, un alkyle C¿1-4?, un cycloalkyle C¿3-7?, un halogène, -CN, NH¿2?, OH ou alcoxy C¿1-4?; ou un sel pharmaceutiquement acceptable desdits composés. A désigne l'un des composés de formule (II), (III), (IV), (V) ou (VI) ; et W, W?1¿, R?2¿, R?3¿, R?4¿, R?5¿, X et Z sont tels que définis dans le descriptif.

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