Tin polyoxaalkanecarboxylates and compositions containing them

Details Tin polyoxaalkanecarboxylates and compositions containing them Tin polyoxaalkanecarboxylates and compositions containing them

C - Chemistry, Metallurgy

07

F

C07F 7/22 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2338801

The invention relates to tin polyoxaalkanecarboxylates having the formula [(R1p R2q Sn)r O s]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is a carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: p = 3, q = 1, r = 1, s = 0 and t - 1, p = 2, q = 2, r = 1, s = 0,and t = 1, p = 2, q = 1, r = 2, s = 1 and t = 2, as well as to anti-tumour compositions, containing as an active ingredient one or more of said tin polyoxaalkanecarboxylates.

L'invention concerne des polyoxaalcanecarboxylates d'étain de formule [(R<1>pR<2>qSn)rOs]t, dans laquelle R<1> représente alkyle C1-C6, linéaire ou ramifié, substitué ou non par un ou plusieurs groupes hydroxyles ou atomes d'halogène, ou un groupe phényle, substitué ou non par un ou plusieurs groupes hydroxyles ou atomes d'halogène, R<2> représente un reste carboxylique choisi parmi (I); (II); (III); ou (IV), p, q, r, s, et t ayant les significations suivantes : p=3, q=1, r=1, s=0, et t=1 ; p=2, q=2, r=1, s=0, et t=1 ; p=2, q=1, r=2, s=1, et t=2. L'invention concerne également des compositions antitumorales, contenant un ou plusieurs polyoxaalcanecarboxylates d'étain comme principe actif.

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