C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/24 (2006.01) A61K 39/395 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2091971
Abstract of the Disclosure TISSUE ANTIGEN AND DIAGNOSTIC METHOD FOR HUMAN OSTEOPOROSIS USING THE SAME An animal tissue antigen for osteoporotic patients that reacts with antibody in a serum of human osteoporotic patients, but does not react with that in normal human serum. Preferably, a specific antigen for osteoporotic patients in rat or mouse epithelium of tongue mucous membrane, epithelium of tracheal mucous membrane, upper lip epidermis or follicular epithelium containing upper lip hair shafts, or a specific antigen for osteoporotic patients contained in cultured cells of a human squamous cell tongue carcinoma cell lines such as SCC-9 and fibroblast cell lines such as NRC-5. Osteoporosis can be both specifically and easily diagnosed by bringing the above-mentioned antigen in contact with the serum of a subject and then testing for the presence of an antigen- antibody reaction.
Akita Mikio
Gotoh Kohsei
Kitamura Kazuyuki
Watanabe Hiroshi
Bereskin & Parr
Hoechst Japan Limited
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