Tissue plasminogen activator analogs having modified growth...

Details Tissue plasminogen activator analogs having modified growth... Tissue plasminogen activator analogs having modified growth...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.23

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341446

Tissue plasminogen activator analogs containing the growth factor domain of native t-PA, the domain having at least one cysteine residue replaced with another amino acid. The t-PA analogs may further contain a variety of substitutions and/or modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.

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