C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/14 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C07D 487/14 (2006.01) C07D 491/14 (2006.01) C07H 15/00 (2006.01) C07H 19/00 (2006.01) C07H 19/23 (2006.01)
Patent
CA 2441412
The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumor cells and exhibit an antitumor effect, as well as processes for their preparation.
La présente invention porte sur des dérivés fluoro sucrés et autres dérivés sucrés d'indolopyrrolocarbazoles, sur leurs sels et hydrates qui présentent une activité sélective contre la topoisomérase I (topo I). Ces dérivés sont utiles pour inhiber la prolifération de cellules tumorales et présentent un effet antitumoral. L'invention porte également sur leurs procédés de préparation.
Bachand Carol
Balusubramanian Neelakantan
Beaulieu Francis
Frennesson David B.
Long Byron Hepler
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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