Toxin detection method

Details Toxin detection method Toxin detection method

C - Chemistry, Metallurgy

07

K

C07K 16/12 (2006.01) A61K 39/09 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2656756

Disclosed are: an antibody directed against Panton-Valentine leukocidin (PVL) toxin derived from Staphylococcus aureus; a method and a kit for the detection of the toxin using the antibody; and a pharmaceutical composition for the treatment of PVL-carrying Staphylococcus aureus, which comprises an antibody directed against Panton-Valentine leukocidin toxin. Specifically, disclosed are: an antibody capable of binding to Panton-Valentine leukocidin F and having no cross-reactivity with LukD and/or HlgB; and an antibody capable of binding to Panton-Valentine leukocidin S and having no cross-reactivity with at least one member selected from LukE, HlgC and HlgA.

La présente invention concerne un anticorps dirigé contre la toxine leucocidine de Panton-Valentine (PVL) dérivée de Staphylococcus aureus; un procédé et un kit pour la détection de la toxine au moyen de l'anticorps; et une composition pharmaceutique pour le traitement de Staphylococcus aureus porteur de PVL, qui comprend un anticorps dirigé contre la toxine leucocidine de Panton-Valentine. Plus particulièrement, l'invention décrit : un anticorps capable de se lier à la leucocidine F de Panton-Valentine et ne présentant pas de réactivité croisée avec LukD et/ou HlgB; et un anticorps capable de se lier à la leucocidine S de Panton-Valentine et ne présentant pas de réactivité croisée avec au moins un membre sélectionné parmi LukE, HlgC et HlgA.

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