Transdermal therapeutical system comprising physostigmine as...

Details Transdermal therapeutical system comprising physostigmine as... Transdermal therapeutical system comprising physostigmine as...

A - Human Necessities

61

K

167/159, 167/240

A61K 9/70 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2006398

The present invention relates to a transdermal therapeutical system for the administration of physostigmine to the skin via a backing layer which is impermeable to active sub- stances, an active substance deposit comprising at least one auxiliary agent with supporting and distributing function in the form of a textile fabric material, a matrix surrounding said deposit from all sides, and optionally a removable protective layer, the matrix of which comprises 10-90%-wt polymeric material selected from the group consisting of polymers on the basis of acrylate and/or methacrylate and esters of hydrogenated colophonium, 0-30%-wt softener on the basis of hydrocarbons and/or esters, and that the active substance deposit immediately after its production comprises 15-85%-wt of a 0.1-70%-wt physostigmine sclution.

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