Transfected cells and methods for treating diabetes

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/22 (2006.01) A61F 2/02 (2006.01) A61K 35/34 (2006.01) A61K 38/28 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2330834

The present invention provides an isolated population of cells containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site and a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsuling cleavage site to produce insulin. The invention also provides an isolated population of cells which further express a hexosamine synthetic pathway enzyme. The invention additionally provides vectors containing an expressible nucleic acid encoding proinsulin containing a proinsulin cleavage site end a glucose-regulated expressible nucleic acid encoding a protease capable of cleaving the proinsulin cleavage site to produce insulin. The invention further provides a method of treating or preventing diabetes by implanting into an individual cells coexpressing proinsulin containing a proinsulin cleavage site and a glucose-regulated protease capable of cleaving the proinsulin cleavage site to produce insulin.

L'invention porte: sur une population isolée de cellules contenant un acide nucléique exprimable codant pour de la proinsuline comportant un site de coupure de la proinsuline et un acide nucléique exprimable régulé par le glucose et codant pour une protéase capable de scinder le site de coupure de la proinsuline pour produire de l'insuline; sur une population isolée de cellules exprimant de plus l'enzyme du processus de synthèse de l'hexosamine; sur des vecteurs contenant un acide nucléique exprimable codant pour de la proinsuline comportant un site de coupure de la proinsuline et un acide nucléique exprimable régulé par le glucose et codant pour une protéase capable de scinder le site de coupure de la proinsuline pour produire de l'insuline; et sur un procédé de traitement ou de prévention du diabète par implantation chez un individu de cellules coexprimant de l'insuline comportant un site de coupure de la proinsuline et une protéase capable de scinder le site de coupure de la proinsuline pour produire de l'insuline.

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