Transgenic mice containing targeted gene disruptions

Details Transgenic mice containing targeted gene disruptions Transgenic mice containing targeted gene disruptions

A - Human Necessities

01

K

A01K 67/027 (2006.01) C07K 14/475 (2006.01) C07K 14/51 (2006.01) C07K 14/705 (2006.01) C12N 9/76 (2006.01) C12N 15/85 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2416292

The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a target gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

La présente invention concerne des animaux transgéniques, ainsi que des compositions et des méthodes relatives à la caractérisation de la fonction du gène. De manière spécifique, la présence invention concerne des souris transgéniques qui présentent des mutations dans un gène cible. Ces souris transgéniques sont très utiles comme modèles pour certaines maladies et permettent d'identifier des agents qui modulent l'expression et la fonction du gène. En outre, l'invention concerne des traitements potentiels destinés à traiter des maladies et des états pathologiques divers.

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