C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/04 (2006.01)
Patent
CA 2615617
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
La présente invention concerne des méthodes et des matières utiles pour apporter un composé transporteur dans une cellule cancéreuse du cerveau et/ou à travers la barrière hémato-encéphalique. La livraison du composé transporteur est effectuée au moyen de peptides de transport de protéines dérivés de protéines de membrane externe Neisseria, telles que Laz. Cette invention se rapporte également à des peptides de transit synthétiques formés du pentapeptide AAEAP, à des méthodes de traitement du cancer et plus spécifiquement du cancer du cerveau, ainsi que d'autres pathologies liées au cerveau et enfin à des méthodes d'imagerie et de diagnostic du cancer, notamment du cancer du cerveau.
Chakrabarty Ananda
Das Gupta Tapas
Fialho Arsenio
Hong Chang
Yamada Tohru
Chakrabarty Ananda
Das Gupta Tapas
Fialho Arsenio
Hong Chang
Smart & Biggar
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