Treatment of aplastic anemia

Details Treatment of aplastic anemia Treatment of aplastic anemia

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2662862

Methods of treating aplastic anemia in a patient and of increasing blood cell production in a patient having aplastic anemia are disclosed. The methods comprise administering to the patient a therapeutically effective amount of an IL-27 antagonist in combination with a pharmaceutically acceptable vehicle. IL-27 antagonists include soluble IL-27RA proteins and antagonists that comprise an antigen-binding site of an antibody.

L'invention a pour objet des procédés de traitement de l'anémie aplastique et d'accroissement de la production de globules sanguins chez un patient atteint d'anémie aplastique. Les procédés comprennent l'administration au patient d'une quantité thérapeutiquement efficace d'un antagoniste de l'IL-27 associé à un véhicule pharmaceutiquement acceptable. Les antagonistes de l'IL-27 comprennent des protéines solubles IL-27RA et des antagonistes qui comprennent eux-mêmes un site de liaison d'antigène d'un anticorps.

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