Treatment of malignant gliomas with tgf-beta inhibitors

Details Treatment of malignant gliomas with tgf-beta inhibitors Treatment of malignant gliomas with tgf-beta inhibitors

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/505 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2551524

The invention concerns methods of treating malignant gliomas, by administering inhibitors of TGF-.beta. the TGF-.beta. signaling pathway, including molecules preferably binding to the type I TGF-.beta. receptor (TGF.beta.-R1). Preferably, the inhibitors are non-peptide small molecules, including quinazoline derivatives. The invention also concerns methods for reversing the TGF-.beta.-mediated effect on glioma cells to make them less refractile to signaling and other immune cells, comprising contacting a glioma cell or tissue in vivo or in vitro, with an inhibitor of TGF-.beta..

L'invention concerne des procédés de traitement de gliomes malins, par administration d'inhibiteurs de TGF-.beta. de la voie de signalisation de TGF-.beta., y compris des molécules se liant de préférence au récepteur de TGF-.beta. type I (TGF.beta.-R1). De préférence, les inhibiteurs sont de petites molécules non peptidiques, y compris des dérivés de quinazoline. L'invention concerne également des procédés pour inverser l'effet médié par TGF-.beta. sur les cellules du gliome afin de les rendre moins réfractiles aux cellules de signalisation et autres cellules immunitaires, qui consistent à mettre en contact une cellule ou un tissu du gliome, in vivo ou in vitro, avec un inhibiteur de TGF-.beta..

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