Tri-substituted ureas as cytokine inhibitors

Details Tri-substituted ureas as cytokine inhibitors Tri-substituted ureas as cytokine inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2564589

The present invention relates to 1, 1, 3-tri-substituted ureas having the formula: (I) whrerein R, R1 and R2 are as defined in the claims, which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 1, 1, 3-tri- substituted ureas which inhibit the extracellular release of inflammatory cytokines, and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

Cette invention concerne des urées 1, 1, 3-tri-substituées présentant la formule (I): dans cette formule, R, R?1¿ et R?2 ¿sont tels que définis dans les revendications; ces urées inhibent la libération extracellulaire de cytokines inflammatoires qui sont responsables d'un ou de plusieurs états pathologiques chez les humains ou chez les mammifères supérieurs. Cette invention concerne également des compositions comprenant ces urées 1, 1, 3-tri-substituées qui inhibent la libération extracellulaire des cytokines inflammatoires, ainsi que des méthodes permettant de prévenir, d'affaiblir ou de réguler les enzymes qui sont supposées être des composants actifs responsables desdits états pathologiques.

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