C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4196 (2006.01) A61K 31/4353 (2006.01) A61K 31/5025 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2649811
The instant invention provides for compounds which comprise substituted triazoloquinazolinones that inhibit CHK1 activity. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting CHK1 activity by administering the compound to a patient in need of treatment of cancer.
La présente invention porte sur des composés qui comprennent des triazoloquinazolinones substituées qui inhibent l'activité CHK1. Cette invention concerne également des compositions renfermant de tels composés inhibiteurs et des méthodes d'inhibition de l'activité CHK1 reposant sur l'administration du composé à un patient nécessitant un traitement anticancéreux.
Arrington Kenneth L.
Brnardic Edward J.
Dudkin Vadim Y.
Fraley Mark E.
Huang Shaei Y.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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