Triazolyl thioamide derivatives

Details Triazolyl thioamide derivatives Triazolyl thioamide derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/266

C07D 413/00 (2006.01) A61K 31/395 (2006.01) C07D 249/14 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01)

Patent

CA 2030775

TRIAZOLYL THIOAMIDE DERIVATES ABSTRACT The invention relates to novel triazolyl thioamides of the general formula (I), Image (I) wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C1-4 alkyl substituent(s), or a group of the formula SR1, wherein R1 stands for straight or branched chained alkyl group comprising 1 to 6 carbon atom(s), or a group of the formula NR2R3, wherein R2 and R3 each represent hydrogen, straight or branched chained C1-4 alkyl or C2-6, alkenyl group, Y denotes C1-4 alkyl optionally bearing one or more hydroxyl or C1-4 alkoxy substituent(s), phenyl-(C1-4 alkyl) optionally bearing on the phenyl ring one or more C1-4 alkoxy group(s), or phenoxy-(C1-4 alkyl) optionally substituted on the phenyl ring by a C1-4 alkyl bearing a heterocyclic group containing a nitrogen atom, and pharmaceutically acceptable acid addition salts there- of. Furthermore the invention relates to a process for preparing these compounds. The compounds according to the invention possess tranquillant, antidepressant, spasmolytic, antiinflammatory, analgesic and antiperistaltic effects.

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