C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/675 (2006.01) C07D 221/16 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2216160
A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds wherein X is N, C or OH and R is (I) or (II) are disclosed.
La présente invention décrit un procédé inhibant la fonction Ras et inhibant par conséquent la croissance anormale des cellules. Le procédé consiste à administrer un composé de formule (1.0) à un système biologique. En particulier, le procédé inhibe la croissance anormale des cellules chez un mammifère tel que l'être humain. L'invention décrit également de nouveaux composés dans lesquels X représente N, C ou CH et R représente (I) ou (II).
Bishop W. Robert
Doll Ronald J.
Mallams Alan K.
Njoroge F. George
Petrin Joanne M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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