C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/00 (2006.01) C07D 221/20 (2006.01)
Patent
CA 2376076
A tricyclic compound of Formula (I): wherein: R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; or R1 and R2 together are oxygen; A is a bond, CH2, CH CH3, CH2 CH2 or C(CH3)2; R3 and R4 are the same or different and are hydrogen, halo, C1-C6 alkyl, C1-C4 alkoxy, trifluoromethyl, NO2, COR6, COOR6 or NR6R7, wherein R6 and R7 are the same or different and are hydrogen, C1-C6 alkyl or benzyl; R5 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, (O=C)-C1-6 alkyl, (O=C)-C2-6 alkenyl, (O=C)-C3-6 cycloalkyl, wherein said alkyl, alkenyl and cycloalkyl groups can be substituted by 1, 2 or 3 groups selected from halo, C3-C6 cycloalkyl, phenyl or substituted phenyl, and salts thereof, are particularly useful for treating, among other indications, neuropathic pain and other CNS disorders.
Cette invention concerne un composé tricyclique de formule I dans laquelle: R?1¿ est hydrogène ou hydroxy; R?2¿ est hydrogène ou hydroxy; ou R?1¿ et R?2¿ ensemble sont oxygène; A est une liaison, CH¿2?, CH CH¿3?, CH¿2? CH¿2? ou C(CH¿3?)¿2?; R?3¿ et R?4¿ sont identiques ou différents et sont hydrogène, halo, alkyle en C¿1?-C¿6?, alcoxy en C¿1?-C¿4?, trifluorométhyle, NO¿2?, COR?6¿, COOR?6¿ ou NR?6¿R?7¿, R?6¿ et R?7¿ étant identiques ou différents et étant hydrogène, alkyle en C¿1?-C¿6? ou benzyle; R?5¿ est hydrogène, alkyle en C¿1-6?, alcényle en C¿2-6?, cycloalkyle en C¿3-6?, (O=C)-C¿1-6? alkyle, (O=C)-C¿2-6? alcényle, (O=C)-C¿3-6? cycloalkyle, les dits groupes alkyle, alcényle et cycloalkyle pouvant être substitués par des groupes 1, 2 ou 3 pris dans halo, cycloalkyle en C¿3?-C¿6?, phényle or phényle substitué. Ce composé et ses sels conviennent particulièrement pour le traitement, entre autres choses des douleurs neuropathiques et autres troubles du système nerveux central.
Calvet Alain
Grouhel Agnes
Hamon Jacques
Jacobelli Henri
Puaud Jocelyne
Smart & Biggar
Warner-Lambert Company
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