C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 221/16 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2420673
The present invention discloses novel tricyclic compounds represented by the formula (1.0), a prodrug thereof, or a pharmaceutically acceptable salt or solvate of the compound or of said prodrug useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising such compounds their preparation as well as methods of using them to treat proliferative diseases such as cancer.
L'invention concerne de nouveaux composés tricycliques représentés par la formule (1.0), un promédicament de ces derniers, ou un sel ou solvate pharmaceutiquement acceptable du composé ou du promédicament, utiles pour inhiber la farnésyl-protéine transférase. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, leur préparation, ainsi que des procédés d'utilisation des compositions pour traiter des maladies prolifératives, comme le cancer.
Alvarez Carmen S.
Baldwin John J.
Bishop Robert W.
Cooper Alan B.
Desai Jagdish A.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pharmacopeia Inc.
Schering Corporation
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