Tricyclic compounds and their use as mglur1 antagonists

Details Tricyclic compounds and their use as mglur1 antagonists Tricyclic compounds and their use as mglur1 antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 239/00 (2006.01) C07D 307/00 (2006.01) C07D 333/00 (2006.01) C07D 471/14 (2006.01) C07D 491/14 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2571012

In its many embodiments, the present invention provides tricyclic compounds of Formula (I) (wherein J1-J4, X, and R1-R5 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

La présente invention concerne, dans plusieurs modes de réalisation, des composés tricycliques représentés par la formule (I) (dans laquelle J1-J4, X, et R1-R5 sont tels que définis dans la description) utilisés comme antagonistes du récepteur du glutamate métabotropique (mGluR), en particulier comme antagonistes sélectifs du récepteur 1 du glutamate métabotropique; des compositions pharmaceutiques contenant lesdits composés; et des méthodes de traitement dans lesquelles sont utilisés lesdits composés et compositions pour traiter les maladies associées au récepteur du glutamate métabotropique (par exemple le mGluR1), telles que, par exemple, la douleur, la migraine, l'anxiété, l'incontinence urinaire et les maladies neurodégénératives telles que la maladie d'Alzheimer.

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