Tricyclic compounds useful for inhibition of farnesyl...

Details Tricyclic compounds useful for inhibition of farnesyl... Tricyclic compounds useful for inhibition of farnesyl...

C - Chemistry, Metallurgy

07

D

C07D 207/12 (2006.01) A61K 31/40 (2006.01) C07C 237/30 (2006.01) C07C 237/32 (2006.01) C07C 237/44 (2006.01) C07D 207/10 (2006.01) C07D 207/20 (2006.01) C07D 207/22 (2006.01) C07D 207/24 (2006.01) C07D 295/08 (2006.01) C07D 295/12 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2266014

Novel tricyclic compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

L'invention concerne de nouveaux composés de formule (1.0), représentés par les composés de formules (1.4) ou (1.5), dans lesquelles R?1¿, R?3¿ et R?4¿ sont sélectionnés indépendamment l'un de l'autre dans le groupe halo. L'invention concerne également des méthodes pour inhiber la farnésyl protéine transférase et la croissance de cellules anormales, telles que des cellules tumorales.

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