Tricyclic derivatives of substituted pyrrole acids as...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) C07D 207/34 (2006.01) C07D 209/70 (2006.01) C07D 313/08 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)

Patent

CA 1185971

ABSTRACT OF THE INVENTION Tricyclic derivatives of substituted pyrrole acids, e.g., substituted 4,10-dihydro-10-oxo-1H- [1]benzoxepino[4,3-b]pyrrole-2-acetic acids or the 5-thia analogs thereof have been prepared via hydrolysis of a precursor or decarboxylation of a precursor-diacid. These tricyclic compounds are found to have high analgesic and anti-inflammatory activities but low ulcerogenic side effects.

406141

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